Integration of Molecular Biomarkers into Clinical Development
نویسندگان
چکیده
The availability of targeted compounds aimed at the molecular pathways involved in oncogenesis has created major opportunities that have led to the development of highly specifi c cancer treatments, with the potential for greater effi cacy and lower toxicity than conventional cytotoxic agents. Imatinib (Gleevec/Glivec) displays the full potential for these new approaches and has revolutionized the treatment of chronic myeloid leukemia (CML), while treatments such as trastuzumab (Herceptin) have transformed the futures of many patients with HER2+ breast cancer.
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